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See the Concerns and Cautions section of the Choline Supplements Review

These were observable as the spontaneous release of NO [67,68], as a counteraction of the adverse effect of a NOS blockade (i.e., L-NAME hypertension and pro-thrombotic effect), a counteraction of the adverse effect of NOS overstimulation (i.e., L-arginine hypotension and anti-thrombotic effect) [67,69], as control of vasomotor tone and as the activation of the Src-Caveolin-1-eNOS pathway [60,61]

(44(3)):406-410 doi:10.1111/jvp.12967

Testing shows the product is 99.6% pure, with an assay result of 99.8%, meaning the material closely matches what it is supposed to be

There is no human clinical trial establishing any effective or safe human dose, oral or injected

Gut health: whether an underlying stomach or intestinal issue is affecting absorption